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文献摘要:虾青素在心血管健康与疾病中的作用
发布时间:2015/9/21 8:45:18  阅读次数:318

        发生氧化应激和产生炎症会导致动脉粥样硬化引起的心血管疾病。然而,维生素E,C和β-胡萝卜素在心血管疾病方面所进行的抗氧化测试表明它们不能有效减少心血管疾病,降低死亡率。虽然这些结果可能有实验设计方面的缺陷,但是,人们一直在寻找新的,更有效的抗氧化物质。虾青素就是一种更强的抗氧化物质,它是一种类胡罗卜素,存在于微藻,真菌,植物,海鲜,火烈鸟及鹌鹑中,具有抗氧化和消炎的作用。有限的短期内的小样本研究已经评估了虾青素的抗氧化能力、消炎作用,同时还调查了它的生物有效性和安全性。到目前为止没有发现明显不良反应,而且研究发现随着虾青素的供应氧化应激和炎症会减弱。利用心脏缺血再灌注模型对几种动物进行研究,表明缺血诱导前无论口服还是注射虾青素都可以起到心肌保护的作用。虽然利用虾青素进行人体临床心血管研究尚未报道,但是鉴于虾青素在心血管实验研究,以及物理化学、抗氧化性及安全性的良好结果,其临床研究势在必行。

Oxidative stress and inflammation are established processes contributing to cardiovascular disease caused by atherosclerosis. However, antioxidant therapies tested in cardiovascular disease such as vitamin E, C and β-carotene have proved unsuccessful at reducing cardiovascular events and mortality. Although these outcomes may reflect limitations in trial design, new, more potent antioxidant therapies are being pursued. Astaxanthin, a carotenoid found in microalgae, fungi, complex plants, seafood, flamingos and quail is one such agent. It has antioxidant and anti-inflammatory effects. Limited, short duration and small sample size studies have assessed the effects of astaxanthin on oxidative stress and inflammation biomarkers and have investigated bioavailability and safety. So far no significant adverse events have been observed and biomarkers of oxidative stress and inflammation are attenuated with astaxanthin supplementation. Experimental investigations in a range of species using a cardiac ischaemia-reperfusion model demonstrated cardiac muscle preservation when astaxanthin is administered either orally or intravenously prior to the induction of ischaemia. Human clinical cardiovascular studies using astaxanthin therapy have not yet been reported. On the basis of the promising results of experimental cardiovascular studies and the physicochemical and antioxidant properties and safety profile of astaxanthin, clinical trials should be undertaken. 
(Fassett R G, Coombes J S. Astaxanthin in cardiovascular health and disease. Molecules. 2012, 17(2): 2030-2048. )
  


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